The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Mar. 13, 2002
Paul Adriaan Jan Janssen, Beerse, BE;
Koen Jeanne Alfons Van Aken, Kortrijk, BE;
Paulus Joannes Lewi, Turnhout, BE;
Lucien Maria Henricus Koymans, Retie, BE;
Marc René DE Jonge, Tilburg, NL;
Jan Heeres, Vosselaar, BE;
Frederik Frans Desire Daeyaert, Beerse, BE;
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Frans Josef Cornelius Compernolle, Herent, BE;
Amuri Kilonda, Kessel-Lo, BE;
Paul Adriaan Jan Janssen, Beerse, BE;
Koen Jeanne Alfons Van Aken, Kortrijk, BE;
Paulus Joannes Lewi, Turnhout, BE;
Lucien Maria Henricus Koymans, Retie, BE;
Marc René de Jonge, Tilburg, NL;
Jan Heeres, Vosselaar, BE;
Frederik Frans Desire Daeyaert, Beerse, BE;
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Frans Josef Cornelius Compernolle, Herent, BE;
Amuri Kilonda, Kessel-Lo, BE;
Janssen Pharmaceutica, N.V., Beerse, BE;
Abstract
This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Ris hydrogen, hydroxy, cyano, amino, mono-or di(Calkyl)amino, formyl, carboxyl, Calkyl, hydroxyCalkyl, polyhaloCalkyl, Calkenyl, Calkynyl, Ccycloalkyl, Calkyloxy, Calkylcarbonyl, aminocarbonyl, —S(═O)—NH, mono-or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkylcarbonyloxy, aryl, arylCalkyl or aryloxy; Ris hydrogen; halo; mercapto; formyl; cyano; carboxy; azido; hydroxy; oxiranyl; amino; mono- or di(Calkyl)amino; formylamino; RRN—C(═O)—; R—N═C(R)—; Calkyl-S(═O)m; aryl-S(═O); optionally substituted Calkenyl; optionally substituted Calkynyl; Calkyloxy; hydroxyCalkyloxy; aminoCalkyloxy; mono- or di(Calkyl)amino-Calkyloxy; Calkylcarbonyl; arylcarbonyl; Hetcarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; aryl; aryloxy; arylCalkyloxy; arylthio; arylCalkylthio; mono- or di(aryl)amino; Het; Hetoxy; Hetthio; HetCalkyloxy; HetCalkylthio; mono- or di(Het)amino; Ccycloalkyl; Ccycloalkyloxy; Ccycloalkylthio; Calkylthio; hydroxyCalkylthio; aminoCalkylthio; mono- or di(Calkyl)aminoCalkylthio; optionally substituted Calkyl; Ror Reach independently represent optionally be substituted phenyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl; —X— is a bivalent radical selected from —NR—, —NH—NH—, —N═N—, —O—, —Calkanediyl-, —C(═O)—, —CHOH—, —S—, —S(═O)—; aryl is optionally substituted phenyl; Het, Hetor Hetrepresent an optionally substituted monocyclic or bicyclic heterocycle; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.