The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2006

Filed:

Aug. 14, 2002
Applicants:

Niall Morrison Barr Martin, Cambridge, GB;

Graeme Cameron Murray Smith, Cambridge, GB;

Roger John Griffin, Newcastle Upon Tyne, GB;

Bernard Thomas Golding, Newcastle Upon Tyne, JP;

Ian Robert Hardcastle, Newcastle Upon Tyne, JP;

Laurent Jean Martin Rigoreau, Sussex, GB;

David Richard Newell, Newcastle Upon Tyne, GB;

Hilary Alan Calvert, Newcastle Upon Tyne, GB;

Nicola Jane Curtin, Newcastle Upon Tyne, GB;

Paul Workman, Surrey, GB;

Florence Irene Raynaud, Surrey, GB;

Bernard Paul Nutley, Surrey, GB;

Inventors:

Niall Morrison Barr Martin, Cambridge, GB;

Graeme Cameron Murray Smith, Cambridge, GB;

Roger John Griffin, Newcastle Upon Tyne, GB;

Bernard Thomas Golding, Newcastle Upon Tyne, JP;

Ian Robert Hardcastle, Newcastle Upon Tyne, JP;

Laurent Jean Martin Rigoreau, Sussex, GB;

David Richard Newell, Newcastle Upon Tyne, GB;

Hilary Alan Calvert, Newcastle Upon Tyne, GB;

Nicola Jane Curtin, Newcastle Upon Tyne, GB;

Paul Workman, Surrey, GB;

Florence Irene Raynaud, Surrey, GB;

Bernard Paul Nutley, Surrey, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/382 (2006.01); C07D 335/02 (2006.01); A61N 5/00 (2006.01); A61K 31/5355 (2006.01); C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein Rand Rare independently hydrogen, an option ally substituted Calkyl group, Cheterocyclyl group, or Caryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and Ris an optionally substituted Cheterocyclyl or Caryl group, and their use as pharmaceuticals, particularly in treating diseases which are retroviral mediated or ameliorated by the inhibition of DNA-PK,


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