The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Nov. 02, 2001
Robert D. Klein, South San Francisco, CA (US);
Mark W. Moore, San Francisco, CA (US);
Arnon Rosenthal, Woodside, CA (US);
Anne M. Ryan, Millbrae, CA (US);
Robert D. Klein, South San Francisco, CA (US);
Mark W. Moore, San Francisco, CA (US);
Arnon Rosenthal, Woodside, CA (US);
Anne M. Ryan, Millbrae, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.