The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Jun. 08, 1995
Diane M. Gajewczyk, Aurora, CA;
Heather A. Boux, Victoria, CA;
Anton Novak, Toronto, CA;
Michel H. Klein, Willowdale, CA;
Diane M. Gajewczyk, Aurora, CA;
Heather A. Boux, Victoria, CA;
Anton Novak, Toronto, CA;
Michel H. Klein, Willowdale, CA;
Sanofi Pasteur Inc., Swiftwater, PA (US);
Abstract
A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxifiedholotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxifiedholotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.