The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2006

Filed:

Jun. 14, 2005
Applicants:

Zhen-wei Cai, Belle Mead, NJ (US);

Louis J. Lombardo, Belle Mead, NJ (US);

Rajeev S. Bhide, Princeton Junction, NJ (US);

Ligang Qian, Hopewell, NJ (US);

Donna D. Wei, Belle Mead, NJ (US);

Stephanie Barbosa, Lambertville, NJ (US);

Inventors:

Zhen-wei Cai, Belle Mead, NJ (US);

Louis J. Lombardo, Belle Mead, NJ (US);

Rajeev S. Bhide, Princeton Junction, NJ (US);

Ligang Qian, Hopewell, NJ (US);

Donna D. Wei, Belle Mead, NJ (US);

Stephanie Barbosa, Lambertville, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.


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