The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2006
Filed:
Mar. 06, 2003
Magnus Pfahl, Solana Beach, CA (US);
Catherine Tachdjian, San Diego, CA (US);
Hussien A. Al-shamma, Encinitas, CA (US);
Andrea Fanjul Giachino, San Diego, CA (US);
Karine Jakubowicz-jaillardon, Villebon sur Yvette, FR;
Jianhua Guo, San Diego, CA (US);
Mohamed Boudjelal, San Diego, CA (US);
James W. Zapf, San Diego, CA (US);
Magnus Pfahl, Solana Beach, CA (US);
Catherine Tachdjian, San Diego, CA (US);
Hussien A. Al-Shamma, Encinitas, CA (US);
Andrea Fanjul Giachino, San Diego, CA (US);
Karine Jakubowicz-Jaillardon, Villebon sur Yvette, FR;
Jianhua Guo, San Diego, CA (US);
Mohamed Boudjelal, San Diego, CA (US);
James W. Zapf, San Diego, CA (US);
Incyte San Diego Inc., Wilmington, DE (US);
Ortho McNeil Pharmaceutical Inc., Rariton, NJ (US);
Abstract
The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Arform a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.