The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2006
Filed:
Oct. 27, 1992
Phillip Dan Cook, San Marcos, CA (US);
Daniel Peter Claude Mcgee, Boulder, CA (US);
Charles John Guinosso, Visia, CA (US);
Phillip Dan Cook, San Marcos, CA (US);
Daniel Peter Claude McGee, Boulder, CA (US);
Charles John Guinosso, Visia, CA (US);
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Compounds are provided containing purine nucleotides that bear moieties X at the 2' position thereof wherein X is R—(R); Ris C-Calkyl, C-Calkenyl or C-Calkynyl; Ris halogen, hydroxyl, thiol, keto, carboxyl, nitro, nitroso, nitrile, trifluoromethyl, trifluoromethoxy, O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aryl, S-aryl, NH-aryl, O-aralkyl, S-aralkyl, NH-aralkyl, amino, N-phthalimido, imidazole, azido, hydrazino, hydroxylamino, isocyanato, sulfoxide, sulfone, sulfide, disulfide, silyl, aryl, heterocycle, carbocycle, intercalator, reporter molecule, conjugate, polyamine, polyamide, polyalkylene glycol, polyether, a group that enhances the pharmacodynamic properties of oligonucleotides, or a group that enhances the pharmacokinetic properties of oligonucleotides; and n is an integer from 0 to about 6. Such compounds are useful for modulating the synthesis of proteins.