The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2006
Filed:
Oct. 12, 2000
Jerry Pelletier, Baie-D'Urfe, CA;
Philippe Gros, St. Lambert, CA;
Mike Dubow, Montreal, CA;
Targanta Therapeutics, Quebec, CA;
Abstract
This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a() DnaI related protein, as well as its variants. The invention also relates to a specific interaction between theDnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by thebacteriophage 77 genome. The phage open reading frame (ORF) product interacts with amino acids 150–313 ofDnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. Accordingly, the invention provides a method for the inhibition of bacterial growth, and the treatment of bacterial infection via the inhibition of DnaI.