The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2006
Filed:
Jan. 09, 2003
Douglas Buechter, Killingworth, CT (US);
Xiaohong Hou, Guilford, CT (US);
William G. Rice, Madison, CT (US);
Christopher W. Marlor, Bethany, CT (US);
Wengang Yang, Branford, CT (US);
Douglas Buechter, Killingworth, CT (US);
Xiaohong Hou, Guilford, CT (US);
William G. Rice, Madison, CT (US);
Christopher W. Marlor, Bethany, CT (US);
Wengang Yang, Branford, CT (US);
Other;
Abstract
The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi-site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.