The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2006
Filed:
Aug. 27, 2004
Edward Hao Mang Koo, La Jolla, CA (US);
Todd E. Golde, Ponte Vedra Beach, FL (US);
Sascha Weggen, Mainz, DE;
Edward Hao Mang Koo, La Jolla, CA (US);
Todd E. Golde, Ponte Vedra Beach, FL (US);
Sascha Weggen, Mainz, DE;
The Regents of the University of California, Oakland, CA (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Abstract
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβlowering agent to a mammal under conditions in which levels of Aβare selectively reduced, levels of Aβare increased, and levels of Aβare unchanged. The invention provides methods and materials for developing and identifying Aβlowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of Aβlowering agents and antioxidants, Aβlowering agents and non-selective secretase inhibitors, as well as Aβlowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing Aβlowering agents, antioxidants, non-selective secretase inhibitors, and/or acetylcholinesterase inhibitors as well as instructions related to dose regimens for Aβlowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.