The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2006
Filed:
Apr. 25, 2002
Piotr J. Czernik, Little Rock, AR (US);
Anna Radominska-pandya, Little Rock, AR (US);
Piotr J. Czernik, Little Rock, AR (US);
Anna Radominska-Pandya, Little Rock, AR (US);
Other;
Abstract
Human UDP-glucuronosyltransferase 2B7 (UGT2B7) protein expression is limited to ovarian surface epithelium cells and that this protein is not present in tumors arising from this cell layer. UDP-glucuronosyltransferase 2B7 protein accumulates in cells when the cells enter stationary phase and growth inhibition. UGT2B7 protein is not expressed in exponentially growing ovarian tumor cells. Overexpression of UGT2B7 protein in human ovarian tumor cells results in cell growth arrest, significant reduction of lipid content and changes in cell morphology. Thus, active UGT2B7 protein expression in tumor cells can be used to decrease cell proliferation and to treat various cancers, whereas UGT2B7 mRNA expression, protein expression and/or enzymatic activity can be used as a tumor specific marker in diagnostic procedures.