The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2006
Filed:
Aug. 08, 2002
Yorikata Sano, Tsukuba, JP;
Kohei Inamura, Tsukuba, JP;
Akira Miyake, Tsukuba, JP;
Hiromichi Yokoi, Tsukuba, JP;
Katsura Nozawa, Tsukuba, JP;
Shinobu Mochizuki, Tsukuba, JP;
Yorikata Sano, Tsukuba, JP;
Kohei Inamura, Tsukuba, JP;
Akira Miyake, Tsukuba, JP;
Hiromichi Yokoi, Tsukuba, JP;
Katsura Nozawa, Tsukuba, JP;
Shinobu Mochizuki, Tsukuba, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
There is provided a method of screening for substance that inhibits cell death induced by activation of PARP, particularly a substance that is useful as a therapeutic and/or preventive agent for rheumatoid arthritis, neuronal death at the time of cerebral ischemia, cell death of the heart after myocardial infarction reperfusion, autoimmune destruction of β-cells of pancreatic islets of Langerhans, cell death after shock, or inflammatory reaction by immunocyte death. Also provided are a novel protein and a novel gene encoding the same. The aforementioned screening method comprises a step of allowing a test substance to contact a cell expressing an LTRPC2 protein under a conditions such that the LTRPC2 protein can be activated, and a step of analyzing inhibition of LTRPC2 protein activation. The aforementioned novel protein is a rat or mouse LTRPC2 protein, and the aforementioned novel gene is a rat or mouse LTRPC2 gene.