The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2006
Filed:
Jan. 25, 2001
Susumu Amano, Kobe, JP;
Masaru Mitsuda, Akashi, JP;
Kenji Inoue, Kakogawa, JP;
Koichi Kinoshita, Kakogawa, JP;
Koki Yamashita, Kobe, JP;
Yasuyoshi Ueda, Himeji, JP;
Susumu Amano, Kobe, JP;
Masaru Mitsuda, Akashi, JP;
Kenji Inoue, Kakogawa, JP;
Koichi Kinoshita, Kakogawa, JP;
Koki Yamashita, Kobe, JP;
Yasuyoshi Ueda, Himeji, JP;
Kaneka Corporation, Osaka, JP;
Abstract
A nitrous acid salt is added at a temperature of 10 to 80° C. to an aqueous solution which contains an optically active 2-aminocarboxylic acid (4) and a protonic acid, the amount of the latter acid being 1 to 3 equivalents to the former, and which has a proton concentration of 0.5 to 2 mol/kg to conduct a reaction to thereby produce an optically active 2-hydroxycarboxylic acid (1). Thionyl chloride and a basic compound are caused to act on the compound (1) to chlorinate it and simultaneously invert the configuration in the 2-position. Thus, an optically active 2-chlorocarboxylic acid chloride (5) is induced. The compound (5) is hydrolyzed to induce an optically active 2-chlorocarboxylic acid (2). The compound (2) is reacted with a thioacetic acid salt to incorporate an acetylthio group thereinto and simultaneously invert the configuration in the 2-position to thereby produce an optically active 2-acetylthiocarboxylic acid (3).