The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2006
Filed:
Mar. 17, 2003
Applicants:
Silvo Zupancic, Novo mesto, SI;
Dusan Krasovec, Sentrupert, SI;
Pavel Zupet, Novo mesto, SI;
Inventors:
Assignee:
KRKA, Tovarna Zdravil, D. D., Novo Mesto, SI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 309/10 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mixture thereof or without solvents. It is characteristic of this reaction that no additional impurities are obtained and that it takes place without the use of additional catalysts and with low excesses of the reagent.