The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2006
Filed:
Apr. 09, 2004
Steven Rosenberg, Oakland, CA (US);
Michael V. Doyle, Oakland, CA (US);
Harold A. Chapman, Newton, MA (US);
Steven Rosenberg, Oakland, CA (US);
Michael V. Doyle, Oakland, CA (US);
Harold A. Chapman, Newton, MA (US);
Chiron Corporation, Emeryville, CA (US);
Brigham and Women's Hospital Harvard Medical School, Boston, MA (US);
Abstract
Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The invention has applications in design of therapeutics for treating disorders characterized by upregulation of uPA and uPAR, and cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostical applications to such disorders.