The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2006
Filed:
Jul. 17, 2002
Applicants:
Dong-eok Lee, Seoul, KR;
Myung-suk OH, Yicheon, KR;
Ki-wan Kim, Seoul, KR;
Bo-sup Chung, Anyang, KR;
Ji-sook Park, Seoul, KR;
Inventors:
Dong-eok Lee, Seoul, KR;
Myung-suk Oh, Yicheon, KR;
Ki-wan Kim, Seoul, KR;
Bo-sup Chung, Anyang, KR;
Ji-sook Park, Seoul, KR;
Assignee:
Cheil Jedang Corporation, Seoul, KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/59 (2006.01); C07K 14/505 (2006.01); C12N 15/00 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
Abstract
Provided is a fusion protein comprising, at its carboxy terminal of human erythropoietin (EPO), a mutant having one to four amino acid substitutions in the carboxy terminal peptide (CTP) fragment of a human chorionic gonadotropin (HCG) β subunit, for increasing an in vivo half-life activity of EPO. The in vivo half-life can be greatly elongated while retaining the intrinsic activity of the EPO, without increasing the sugar chain content.