The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2006
Filed:
Jul. 08, 2003
Mladen Mercep, Zagreb, HR;
Milan Mesic, Zagreb, HR;
Linda Tomaskovic, Zagreb, HR;
Stribor Markovic, Karlovac, HR;
Oresta Makaruha, Zagreb, HR;
Visnja Poljak, Zadar, HR;
Mladen Mercep, Zagreb, HR;
Milan Mesic, Zagreb, HR;
Linda Tomaskovic, Zagreb, HR;
Stribor Markovic, Karlovac, HR;
Oresta Makaruha, Zagreb, HR;
Visnja Poljak, Zadar, HR;
Pliva-Istrazivacki Institut D.o.o., Zagreb, HR;
Abstract
The present invention relates (a) to new compounds represented by Formula I:wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, S represents a steroid subunit (steroid moiety) derived from steroid drug with anti-inflammatory activity and L represents a linker molecule linking M and S, (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals. Such compounds inhibit many cytokines and immune mediators involved in immune responses which cause inflammation, allergy, or alloimmunity, including without limitation IL-1, 2, 4, 5, 6, 10, 12, GMCSF, ICAM, and TNF-α. Importantly, anti-inflammatory steroids exert a direct anti-inflammatory effect through binding to the glucocorticosteroid receptor.