The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2006

Filed:

Oct. 12, 2004
Applicants:

Yoshinori Kyotani, Higashiyamato, JP;

Tomoyuki Koshi, Shiki, JP;

Hiromichi Shigyo, Fuchu, JP;

Hideo Yoshizaki, Sayama, JP;

Takahiro Kitamura, Higashimurayama, JP;

Shunji Takemura, Hachioji, JP;

Kyoko Yasuoka, Higashiyamato, JP;

Junko Totsuka, Asaka, JP;

Seiichi Sato, Suginami-ku, JP;

Inventors:

Yoshinori Kyotani, Higashiyamato, JP;

Tomoyuki Koshi, Shiki, JP;

Hiromichi Shigyo, Fuchu, JP;

Hideo Yoshizaki, Sayama, JP;

Takahiro Kitamura, Higashimurayama, JP;

Shunji Takemura, Hachioji, JP;

Kyoko Yasuoka, Higashiyamato, JP;

Junko Totsuka, Asaka, JP;

Seiichi Sato, Suginami-ku, JP;

Assignee:

Kowa Co., Ltd., Nagoya, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/58 (2006.01); A61K 31/50 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having the formula (1): wherein Rrepresents an alkyl or alkenyl group, Rand Reach independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or Rand Rmay be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1β production, high water solubility and good oral absorbability.


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