The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2006
Filed:
Dec. 16, 2002
Steven L. Goldberg, Basking Ridge, NJ (US);
Paul M. Cino, Bound Brook, NJ (US);
Ramesh N. Patel, Bridgewater, NJ (US);
Venkata B. Nanduri, East Brunswick, NJ (US);
Robert M. Johnston, Whitehouse Station, NJ (US);
Steven L. Goldberg, Basking Ridge, NJ (US);
Paul M. Cino, Bound Brook, NJ (US);
Ramesh N. Patel, Bridgewater, NJ (US);
Venkata B. Nanduri, East Brunswick, NJ (US);
Robert M. Johnston, Whitehouse Station, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
This invention relates to a recombinantformate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encodingFDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinantFDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind toFDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolatedFDH nucleic acids, polypeptides, and antibodies, and methods of usingFDH in various reactions for industrial or pharmaceutical applications.