The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
Feb. 14, 2003
Charles R. Scaf, San Francisco, CA (US);
Nicolas Peyret, Foster City, CA (US);
Francisco M. DE LA Vega, San Mateo, CA (US);
Ryan T. Koehler, Hayward, CA (US);
Eugene G. Spier, Palo Alto, CA (US);
Charles R. Scaf, San Francisco, CA (US);
Nicolas Peyret, Foster City, CA (US);
Francisco M. De La Vega, San Mateo, CA (US);
Ryan T. Koehler, Hayward, CA (US);
Eugene G. Spier, Palo Alto, CA (US);
Applera Corporation, Foster City, CA (US);
Abstract
Methods for determining the binding affinity of a probe to a target or targets in a polynucleotide composite using an automated system. Such methods determine relative binding sites based on thermodynamic principles, using a thermodynamic alphabet and a thermodynamic scoring matrix, with appropriate computer software, such as BLASTP. The invention also provides methods for designing polynucleotide probes to be used in hybridization assays, and minimizing the occurrence of cross-hybridization.