The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2006

Filed:

Jul. 21, 2003
Applicants:

Yi Chen, Nutley, NJ (US);

Andrzej Robert Daniewski, Clifton, NJ (US);

William Harris, Henlow, GB;

Marek Michal Kabat, Nutley, NJ (US);

Emily Aijun Liu, Nutley, NJ (US);

Jin-jun Liu, Warren, NJ (US);

Kin-chun Luk, North Caldwell, NJ (US);

Christophe Michoud, New York, NY (US);

Inventors:

Yi Chen, Nutley, NJ (US);

Andrzej Robert Daniewski, Clifton, NJ (US);

William Harris, Henlow, GB;

Marek Michal Kabat, Nutley, NJ (US);

Emily Aijun Liu, Nutley, NJ (US);

Jin-Jun Liu, Warren, NJ (US);

Kin-Chun Luk, North Caldwell, NJ (US);

Christophe Michoud, New York, NY (US);

Assignee:

Hoffman-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 25/00 (2006.01); A01N 43/90 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR an FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.


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