The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
Feb. 08, 2002
Alison A. Mccormick, Vacaville, CA (US);
Daniel Tusé, Menlo Park, CA (US);
Stephen J. Reinl, Sacramento, CA (US);
John A. Lindbo, Vacaville, CA (US);
Thomas H. Turpen, Vacaville, CA (US);
Alison A. McCormick, Vacaville, CA (US);
Daniel Tusé, Menlo Park, CA (US);
Stephen J. Reinl, Sacramento, CA (US);
John A. Lindbo, Vacaville, CA (US);
Thomas H. Turpen, Vacaville, CA (US);
Large Scale Biology Corporation, Vacaville, CA (US);
Abstract
A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding the polypeptide and is obtainable from the plant in correctly folded, preferably soluble form without a need for denaturation and renaturation. This plant-produced polypeptide is immunogenic without a need for exogenous adjuvants or other immunostimulatory materials. The polypeptide is preferably an scFv molecule that bears the idiotype of the surface immunoglobulin of a non-Hodgkin's (or B cell) lymphoma. Upon administration to a subject with lymphoma, the plant-produced, tumor-unique scFv polypeptide induces an idiotype-specific antibody or cell-mediated immune response against the lymphoma.