The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
Apr. 29, 2004
Nnochiri N. Ekwuribe, Cary, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Aslam M. Ansari, Rockville, MD (US);
Balasingam Radhakrishnan, Chapel Hill, NC (US);
Amy L. Odenbaugh, Morrisville, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Aslam M. Ansari, Rockville, MD (US);
Balasingam Radhakrishnan, Chapel Hill, NC (US);
Amy L. Odenbaugh, Morrisville, NC (US);
Nobex Corporation, Durham, NC (US);
Abstract
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.