The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2006
Filed:
May. 03, 2002
Applicants:
Roy Curtiss, Iii, St. Louis, MO (US);
Cheryl A. Nickerson, River Ridge, LA (US);
Inventors:
Roy Curtiss, III, St. Louis, MO (US);
Cheryl A. Nickerson, River Ridge, LA (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 39/112 (2006.01); C12N 15/74 (2006.01); C12N 1/21 (2006.01);
U.S. Cl.
CPC ...
Abstract
Attenuated immunogenic bacteria having an RpoSphenotype, in particular,serotypehaving an RpoSphenotype and methods therefor are disclosed. Thehave in addition to an RpoSphenotype, an inactivating mutation in one or more genes which render the microbe attenuated, and a recombinant gene capable of expressing a desired protein. Theare attenuated and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for genes and gene products. Also disclosed are methods for preparing the vaccine delivery vehicles.