The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2006
Filed:
Dec. 14, 2001
Karl H. Weisgraber, Walnut Creek, CA (US);
Robert V. Farese, San Francisco, CA (US);
Robert Raffai, San Francisco, CA (US);
Li-ming Dong, Palo Alto, CA (US);
Karl H. Weisgraber, Walnut Creek, CA (US);
Robert V. Farese, San Francisco, CA (US);
Robert Raffai, San Francisco, CA (US);
Li-Ming Dong, Palo Alto, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.