The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2006
Filed:
Dec. 16, 2004
Applicants:
J. David Rozzell, Jr., Burbank, CA (US);
Spiros Kambourakis, Pasadena, CA (US);
Inventors:
J. David Rozzell, Jr., Burbank, CA (US);
Spiros Kambourakis, Pasadena, CA (US);
Assignee:
BioCatalytics, Inc., Pasadena, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 211/70 (2006.01); C07D 211/82 (2006.01); C07D 213/55 (2006.01); C07D 333/22 (2006.01); C07C 229/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Hydroxy-amino acids are provided and are prepared by contacting a substituted β-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting the reduction of the keytone group to an alcohol. Only one of the ester functional groups is regioselectively hydrolyzed to the corresponding carboxylic acid, whereby a non-hydrolyzed ester functional group remains. The carboxylic acid is converted to an amine to produce a hydroxy-amino acid.