The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2006
Filed:
Apr. 05, 2004
Mark A. Sanner, Old Saybrook, CT (US);
Chris J. Helal, Mystic, CT (US);
Christoper B. Cooper, Lawrenceville, NJ (US);
Frank S. Menniti, Mystic, CT (US);
Patricia A. Seymour, Westerly, RI (US);
Michael K. Ahlijanian, Mystic, CT (US);
Anabella Villalobos, Niantic, CT (US);
Lit-fui Lau, Mystic, CT (US);
Mark A. Sanner, Old Saybrook, CT (US);
Chris J. Helal, Mystic, CT (US);
Christoper B. Cooper, Lawrenceville, NJ (US);
Frank S. Menniti, Mystic, CT (US);
Patricia A. Seymour, Westerly, RI (US);
Michael K. Ahlijanian, Mystic, CT (US);
Anabella Villalobos, Niantic, CT (US);
Lit-Fui Lau, Mystic, CT (US);
Pfizer Inc., New York, NY (US);
Abstract
The invention provides compounds of formula 1 wherein R, R, R, and Rare as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating and preventing diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.