The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2006
Filed:
Aug. 03, 1999
Kenneth Cornell Kasper, Monte Sereno, CA (US);
Henry Jeong, Palo Alto, CA (US);
Dariush Davalian, San Jose, CA (US);
Hshiou-ting Liu, Milpitas, CA (US);
Paul Levi Miller, South San Francisco, CA (US);
Denise Leah Williams, San Jose, CA (US);
Kenneth Cornell Kasper, Monte Sereno, CA (US);
Henry Jeong, Palo Alto, CA (US);
Dariush Davalian, San Jose, CA (US);
Hshiou-ting Liu, Milpitas, CA (US);
Paul Levi Miller, South San Francisco, CA (US);
Denise Leah Williams, San Jose, CA (US);
Dade Behring Inc., Deerfield, IL (US);
Abstract
An IgGλ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several tacrolimus metabolites. This antibody is suitable for performance of immunoassays such as homogeneous immunoassays to detect or determine the presence or concentration of tacrolimus in samples such as blood samples. The invention further includes derivatives of tacrolimus derivatized at a non-binding portion of the molecule useful in immunizing antibody-producing animals and in producing such monoclonal antibodies, as well as labeled derivatives of tacrolimus useful as tacrolimus analogues in such assays. The invention further includes immunoassay methods for the detection of tacrolimus and test kits useful in performing such immunoassays.