The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2006
Filed:
Jan. 08, 2002
Arthur C Ley, Newton, MA (US);
Sonia K Guterman, Belmont, MA (US);
William Markland, Milford, MA (US);
Rachel B Kent, Boxborough, MA (US);
Bruce L Roberts, Milford, MA (US);
Robert C Ladner, Ijamsville, MD (US);
Arthur C Ley, Newton, MA (US);
Sonia K Guterman, Belmont, MA (US);
William Markland, Milford, MA (US);
Rachel B Kent, Boxborough, MA (US);
Bruce L Roberts, Milford, MA (US);
Robert C Ladner, Ijamsville, MD (US);
Dyax Corp., Cambridge, MA (US);
Abstract
Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.