The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Nov. 16, 2001
James M. Robl, Brandon, SD (US);
Richard A. Goldsby, Leverett, MA (US);
Stacy E. Ferguson, Dallas, TX (US);
Yoshimi Kuroiwa, Takasaki, JP;
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
Barbara A. Osborne, Leverett, MA (US);
James M. Robl, Brandon, SD (US);
Richard A. Goldsby, Leverett, MA (US);
Stacy E. Ferguson, Dallas, TX (US);
Yoshimi Kuroiwa, Takasaki, JP;
Kazuma Tomizuka, Takasaki, JP;
Isao Ishida, Isehara, JP;
Barbara A. Osborne, Leverett, MA (US);
Kirin Beer Kabushiki Kaisha, Tokyo, JP;
Hematech, LLC, Westport, CT (US);
Abstract
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.