The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Apr. 05, 2004
Sui Xiong Cai, San Diego, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
John Drewe, Carlsbad, CA (US);
P. Sanjeeva Reddy, San Diego, CA (US);
Han-zhong Zhang, San Diego, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
John Drewe, Carlsbad, CA (US);
P. Sanjeeva Reddy, San Diego, CA (US);
Han-Zhong Zhang, San Diego, CA (US);
Cytovia, Inc., San Diego, CA (US);
Abstract
The present invention is directed to substituted N'-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar, Ar, and R–Rare defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.