The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 11, 2006

Filed:

Feb. 11, 2003
Applicants:

Chih-hung Lee, Vernon Hills, IL (US);

Erol K. Bayburt, Gurene, IL (US);

Stanley Didomenico, Jr., Richmond, IL (US);

Irene Drizin, Wadsworth, IL (US);

Arthur R. Gomtsyan, Vernon Hills, IL (US);

John R. Koenig, Chicago, IL (US);

Richard J. Perner, Gurnee, IL (US);

Robert G. Schmidt, Jr., Waukegan, IL (US);

Sean C. Turner, Evanston, IL (US);

Tammie K. White, Gurnee, IL (US);

Guo Zhu Zheng, Lake Bluff, IL (US);

Inventors:

Chih-Hung Lee, Vernon Hills, IL (US);

Erol K. Bayburt, Gurene, IL (US);

Stanley DiDomenico, Jr., Richmond, IL (US);

Irene Drizin, Wadsworth, IL (US);

Arthur R. Gomtsyan, Vernon Hills, IL (US);

John R. Koenig, Chicago, IL (US);

Richard J. Perner, Gurnee, IL (US);

Robert G. Schmidt, Jr., Waukegan, IL (US);

Sean C. Turner, Evanston, IL (US);

Tammie K. White, Gurnee, IL (US);

Guo Zhu Zheng, Lake Bluff, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); C07D 217/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The isoquinoline compounds of formula (I)are VR1 antagonists that are useful in treating pain, inflammation, thermal hyperalgesia, urinary incontinence and bladder over activity. The 'R', 'Z' and “L” variables are defined in the disclosure and the “X” variables are defined as follows:


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