The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Jan. 04, 2001
Doreen Mary Ashworth, Southampton, GB;
Gary Robert William Pitt, Hampshire, GB;
Peter Hudson, Copenhagen S, DK;
Christopher Martyn Yea, Romsey, GB;
Richard Jeremy Franklin, Wokingham, GB;
Doreen Mary Ashworth, Southampton, GB;
Gary Robert William Pitt, Hampshire, GB;
Peter Hudson, Copenhagen S, DK;
Christopher Martyn Yea, Romsey, GB;
Richard Jeremy Franklin, Wokingham, GB;
Ferring BV, Hoofddorp, NL;
Abstract
This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, Vand Vare both H, OMe or F, or one of Vand Vis Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N, NH, NHBn or NH-acyl and the other is H, or Vand Vtogether are ═O, —O(CH)O— or —S(CH)S—; Wis either O or S; Xand Xare both H, or together are ═O or ═S; Y is ORor NRR; R, R, Rand Rare independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; Ris selected from H and lower alkyl; Rand Rare independently selected from H and lower alkyl, or together are —(CH)—; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.