The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Apr. 16, 2004
Victor Gurewich, Cambridge, MA (US);
John N. Williams, Boston, MA (US);
Jian-ning Liu, Brighton, MA (US);
Paolo Sarmientos, Lecco, IT;
Massimiliano Pagani, Castelli Calepio, IT;
Victor Gurewich, Cambridge, MA (US);
John N. Williams, Boston, MA (US);
Jian-Ning Liu, Brighton, MA (US);
Paolo Sarmientos, Lecco, IT;
Massimiliano Pagani, Castelli Calepio, IT;
Thrombolytic Science, Inc., Boston, MA (US);
Abstract
It has now been discovered that certain mutant forms of pro-urokinase ('pro-UK'), such as so-called pro-UK mutant 'M5' (Lys→His), perform in the manner of pro-UK in lysing “bad” blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called “good” blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of other known thrombolytic agents has been too risky or even contraindicated.