The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 04, 2006

Filed:

Sep. 27, 2002
Applicants:

Bruce Alan Pfeffer, Fairport, NY (US);

Rosemarie Beth Flick, Copiaque, NY (US);

Naveed Bin Kamal Shams, Duluth, GA (US);

Stephen Paul Bartels, Pittsford, NY (US);

Inventors:

Bruce Alan Pfeffer, Fairport, NY (US);

Rosemarie Beth Flick, Copiaque, NY (US);

Naveed Bin Kamal Shams, Duluth, GA (US);

Stephen Paul Bartels, Pittsford, NY (US);

Assignee:

Bausch & Lomb Inc., Rochester, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); A61K 31/44 (2006.01); C09D 211/02 (2006.01); C09D 207/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Small organic molecules capable of effecting a 'pharmacological trabeculocanalotomy' in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.


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