The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2006
Filed:
Jul. 30, 1999
Erkki I Ruoslahti, Rancho Santa Fe, CA (US);
Erkki Koivunen, Hyvinkaa, FI;
Erkki I Ruoslahti, Rancho Santa Fe, CA (US);
Erkki Koivunen, Hyvinkaa, FI;
La Jolla Cancer Research Foundation, San Diego, CA (US);
Abstract
This invention is directed to novel integrin binding peptides. These peptides bind to α- of α-containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RXETXWX[SEQ ID NO:1] (especially RRETAWA [SEQ ID NO:8]); RGDGX [SEQ ID NO:2], in which X is an amino acid with a hydrophobic, aromatic side chain; the double cyclic CXCRGDCXC [SEQ ID NO:15]; and RLD. The peptides generally exhibit their highest binding affinity when they assume a conformationally stabilized configuration. This invention also provides methods of using these peptides.