The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2006

Filed:

Oct. 29, 2003
Applicants:

Guixue Yu, Lawrenceville, NJ (US);

John Macor, Guilford, CT (US);

Timothy Herpin, Princeton, NJ (US);

R. Michael Lawrence, Yardley, PA (US);

George C. Morton, Collegeville, PA (US);

Rejean Ruel, Saint-Lambert, CA;

Graham S. Poindexter, Old Saybrook, CT (US);

Edward H. Ruediger, Greenfield Park, CA;

Carl Thibault, Mascouche, CA;

Inventors:

Guixue Yu, Lawrenceville, NJ (US);

John Macor, Guilford, CT (US);

Timothy Herpin, Princeton, NJ (US);

R. Michael Lawrence, Yardley, PA (US);

George C. Morton, Collegeville, PA (US);

Rejean Ruel, Saint-Lambert, CA;

Graham S. Poindexter, Old Saybrook, CT (US);

Edward H. Ruediger, Greenfield Park, CA;

Carl Thibault, Mascouche, CA;

Assignee:

Bristol-Myers Squibb Co., Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/445 (2006.01); C07D 401/04 (2006.01); C07D 413/04 (2006.01); C07D 211/70 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having the formula (I), G is a novel side chain selected from Calkenyl, A-aryl, —OR, heteroaryl, A-cyano, A—OR, A—C(═O)R, A—COR, A—C(═O)NRR, A—OC(═O)R, A—NRC(═O)R, A—OC(═O)NRR, A—NRCOR, A—NRSOR, A—SOR, A—NRC(═O)NRR, and A—SR; or when y is 0 or when W is not NHR, G may be A-heterocyclo, wherein Ais a bond, Calkylene or C-alkenylene, Ais Calkylene or Calkenylene, and Ais Calkenylene; W is selected from —NRR, —OR, —NRC(═O)R, —NRCOR, amidino, guanidino, or a heteroaryl, heterocyclo or Ccycloalkyl as defined in the specification, and X and Rthrough Rare as defined in the specification, are effective as modulators of melanocortin-receptors, particularly MC-1R and MC-4R.


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