The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2006

Filed:

Jun. 25, 2002
Applicants:

Raymond J. Andersen, Vancouver, CA;

Michel Roberge, Vancouver, CA;

Robert A. Britton, Cambridge, CA;

E. Dilip DE Silva, Vancouver, CA;

Inventors:

Raymond J. Andersen, Vancouver, CA;

Michel Roberge, Vancouver, CA;

Robert A. Britton, Cambridge, CA;

E. Dilip De Silva, Vancouver, CA;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7056 (2006.01); A61K 31/7048 (2006.01); C07H 17/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.


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