The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2006
Filed:
Jan. 18, 2002
Leo Liu, Weston, MA (US);
Lucinda Burnam, Somerville, MA (US);
Ann Sluder, Burlington, MA (US);
Elizabeth Link, Brentwood, TN (US);
Beth Westlund, Brookline, MA (US);
Leo Liu, Weston, MA (US);
Lucinda Burnam, Somerville, MA (US);
Ann Sluder, Burlington, MA (US);
Elizabeth Link, Brentwood, TN (US);
Beth Westlund, Brookline, MA (US);
Cambria Biosciences LLC, Bedford, MA (US);
Abstract
The invention provides a method of identifying anti-nematode compounds and further provides transgenic nematodes that may be used to practice the method. In particular, the invention provides a screen for compounds that inhibit a nematode secretion pathway e.g, compounds that inhibit the secretion of proteins by nematodes. The transgenic nematodes express reporters for nematode secreted proteins. In preferred embodiments of the invention the screen is performed using, i.e., certain embodiments of the invention utilizeandsecretory pathways as a model system for parasitic nematodes and parasitic nematode secretion pathways. The invention also provides pharmaceutical compositions that may be used in the treatment and prevention of nematode infection in humans and animals and anti-nematode agents that may be used to protect plants from plant-parasitic nematodes. In addition, the invention provides a genetic screen for identifying additional targets for anti-nematode compounds.