The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2006
Filed:
Jul. 25, 2001
Vinod Kumar Kansal, Mandideep, IN;
Sunil Gurudatt Bhat, Mandideep, IN;
Tanguturi Venkata Marutikumar, Mandideep, IN;
Yuvaraj Atmaram Chavan, Mandideep, IN;
Ramanathan Sankaran, Mumbai, IN;
Vinod Kumar Kansal, Mandideep, IN;
Sunil Gurudatt Bhat, Mandideep, IN;
Tanguturi Venkata Marutikumar, Mandideep, IN;
Yuvaraj Atmaram Chavan, Mandideep, IN;
Ramanathan Sankaran, Mumbai, IN;
Lupin Limited, Maharashtra, IN;
Abstract
A process for preparation of cefuroxime axetil of formula (I) of at least 96% purity and substantially free of analogous Δ-isomer of formula (II) and other impurities. The process comprises reacting cefuroxime acid of formula (III) with (R,S)-1-acetoxyethyl bromide of formula (IV), and a Group I or II metal carbonate in the presence of a compound of formula (V),MHPO  (V)wherein M is Group I or II metal; m is 1, 2, 3; n is 0, 1, 2, or 4; q is 1 or 2; r is 4, 7 or 8; in the presence of a Calcohol and a polar tertiary amide solvent selected from N,N-dimethylacetamide, N,N-dimethylformamide, N,N-dimetheylpropionamide, N,N-diethylacetamide, N,N-diethylformamide and N,N-diethylpropionamide at a temperature ranging from about −30 to +30° C. and subjecting the product thus obtained to a desired step of purification.
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