The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2006
Filed:
Oct. 05, 2000
Applicants:
Tomoki Todo, Belmont, MA (US);
Samuel D. Rabkin, Lynn, MA (US);
Robert L. Martuza, Cambridge, MA (US);
Inventors:
Tomoki Todo, Belmont, MA (US);
Samuel D. Rabkin, Lynn, MA (US);
Robert L. Martuza, Cambridge, MA (US);
Assignee:
Georgetown University, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/12 (2006.01); A61K 39/245 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containing such a gene is effective in tumor suppression.