The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2006
Filed:
Aug. 13, 2002
Michael B. Chancellor, Pittsburgh, PA (US);
Matthew O. Fraser, Apex, NC (US);
Yao-chi Chuang, Kaohsiung Hsein, TW;
William C. DE Groat, Pittsburgh, PA (US);
Leaf Huang, Pittsburgh, PA (US);
Naoki Yoshimura, Pittsburgh, PA (US);
Michael B. Chancellor, Pittsburgh, PA (US);
Matthew O. Fraser, Apex, NC (US);
Yao-Chi Chuang, Kaohsiung Hsein, TW;
William C. de Groat, Pittsburgh, PA (US);
Leaf Huang, Pittsburgh, PA (US);
Naoki Yoshimura, Pittsburgh, PA (US);
University of Pittsburgh, Pittsburgh, PA (US);
Abstract
The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such astoxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.