The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2006

Filed:

Nov. 22, 2002
Applicants:

Tamara Ladduwahetty, London, GB;

Angus Murray Macleod, Bishops Stortford, GB;

Kevin John Merchant, Ware, GB;

Francine Sternfeld, London, GB;

Inventors:

Tamara Ladduwahetty, London, GB;

Angus Murray MacLeod, Bishops Stortford, GB;

Kevin John Merchant, Ware, GB;

Francine Sternfeld, London, GB;

Assignee:

Merck Sharp & Dohme Ltd., Hoddesdon, GB;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 261/08 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); A61K 31/422 (2006.01); A61K 31/4418 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides compounds of formula I: in which: one of X and Y is a nitrogen atom substituted by a group Rand the other is a carbon atom substituted by an isoxazole group substituted on its carbon atoms by groups Rand R; one of Rand Ris hydrogen; either all of W, W, Wand Ware carbon or one of W, W, Wand Wis nitrogen and the rest are carbon; and Rand Rare, independently, a small group, heteroaromatic ring or a 4–7 membered cyclic amine ring; processes for making them; pharmaceutical composition containing them; their use in therapy, particularly for enhancing cognition in conditions such as Alzheimer's Disease; and methods of treatment using them.


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