The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2006

Filed:

Jan. 15, 2002
Applicants:

Charles M. Cohen, Medway, MA (US);

Marc F. Charette, Needham, MA (US);

Thangavel Kuberasampath, Medway, MA (US);

David C. Rueger, Hopkinton, MA (US);

Hermann Oppermann, Medway, MA (US);

Roy H. L. Pang, Etna, NH (US);

Engin Ozkaynak, Milford, MA (US);

John E. Smart, Weston, MA (US);

Inventors:

Charles M. Cohen, Medway, MA (US);

Marc F. Charette, Needham, MA (US);

Thangavel Kuberasampath, Medway, MA (US);

David C. Rueger, Hopkinton, MA (US);

Hermann Oppermann, Medway, MA (US);

Roy H. L. Pang, Etna, NH (US);

Engin Ozkaynak, Milford, MA (US);

John E. Smart, Weston, MA (US);

Assignee:

Curis, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/51 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.


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