The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Dec. 30, 1999
Thomas J. Gardella, Needham, MA (US);
Henry M. Kronenberg, Belmont, MA (US);
John T. Potts, Jr., Newton, MA (US);
Harald Jüppner, Cambridge, MA (US);
Thomas J. Gardella, Needham, MA (US);
Henry M. Kronenberg, Belmont, MA (US);
John T. Potts, Jr., Newton, MA (US);
Harald Jüppner, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and (1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.