The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Jun. 10, 2003
Ronald M. Evans, La Jolla, CA (US);
David J. Mangelsdorf, Duncanville, TX (US);
Richard A. Heyman, Encinitas, CA (US);
Marcus F. Boehm, San Diego, CA (US);
Gregor Eichele, Houston, TX (US);
Christina Thaller, Houston, TX (US);
Ronald M. Evans, La Jolla, CA (US);
David J. Mangelsdorf, Duncanville, TX (US);
Richard A. Heyman, Encinitas, CA (US);
Marcus F. Boehm, San Diego, CA (US);
Gregor Eichele, Houston, TX (US);
Christina Thaller, Houston, TX (US);
The Salk Institute for Biological Studies, La Jolla, CA (US);
Baylor College of Medicine, Waco, TX (US);
Ligand Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.