The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Jul. 09, 2001
Hidenori Nakajima, Tsukuba, JP;
Akito Tanaka, Tsukuba, JP;
Minoru Yoshida, Kawaguchi, JP;
Sueharu Horinouchi, Tokyo, JP;
Hidenori Nakajima, Tsukuba, JP;
Akito Tanaka, Tsukuba, JP;
Minoru Yoshida, Kawaguchi, JP;
Sueharu Horinouchi, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
The present invention relates to reduced FK228 of the formula (I) wherein Rand Rare the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.