The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Sep. 10, 2003
Malavi Madireddi, Lawrenceville, NJ (US);
Malavi Madireddi, Lawrenceville, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention relates to (a) the establishment of a direct consequence to the mitochondrial import of phosphorylated p66and its association with prohibitin, and (b) to a potential function for the prohibitin-p66complex in the mitochondrial membrane depolarization process that governs metabolic events such as bioenergetics and free radical formation. The present invention can also be employed as a tool for identifying pharmaceutically active compounds that disrupt the prohibitin-p66interaction, thereby providing treatment options for aging-related diseases such as diabetes, cardiovascular, osteoporosis, cancer and neurodegenerative diseases.