The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2006

Filed:

Dec. 15, 2003
Applicants:

Allen J. Borchardt, San Diego, CA (US);

Robert Steven Kania, San Diego, CA (US);

Cynthia L. Palmer, La Mesa, CA (US);

Inventors:

Allen J. Borchardt, San Diego, CA (US);

Robert Steven Kania, San Diego, CA (US);

Cynthia L. Palmer, La Mesa, CA (US);

Assignee:

Agouron Pharmaceuticals, Inc., La Jolla, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/416 (2006.01); C07D 213/06 (2006.01); C07D 237/26 (2006.01);
U.S. Cl.
CPC ...
Abstract

Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.


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