The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2006
Filed:
Jul. 28, 2000
Applicants:
Samuel R. Denmeade, Ellicott City, MD (US);
John T. Isaacs, Pheonix, MD (US);
Hans Lilja, S-239 35 Skanor, SE;
Inventors:
Samuel R. Denmeade, Ellicott City, MD (US);
John T. Isaacs, Pheonix, MD (US);
Hans Lilja, S-239 35 Skanor, SE;
Assignee:
Other;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); C07K 14/81 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.